Biomedical and Translational Informatics Laboratory

Publications - 2012

  • Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Patrick T. Ellinor, Kathryn L. Lunetta, Christine M. Albert, Nicole L. Glazer, Marylyn D. Ritchie, Albert V. Smith, Dan E. Arking, Martina Muller-Nurasyid, Bouwe P. Krijthe, Steven A. Lubitz, Joshua C. Bis, Mina K. Chung, Marcus Dorr, Kouichi Ozaki, Jason D. Roberts, J. Gustav Smith, Arne Pfeufer, Moritz F. Sinner, Kurt Lohman, Jingzhong Ding, Nicholas L. Smith, Jonathan D. Smith, Michiel Rienstra, Kenneth M. Rice, David R. Van Wagoner, Jared W. Magnani, Reza Wakili, Sebastian Clauss, Jerome I. Rotter, Gerhard Steinbeck, Lenore J. Launer, Robert W. Davies, Matthew Borkovich, Tamara B. Harris, Honghuang Lin, Uwe Volker, Henry Volzke, David J. Milan, Albert Hofman, Eric Boerwinkle, Lin Y. Chen, Elsayed Z. Soliman, Benjamin F. Voight, Guo Li, Aravinda Chakravarti, Michiaki Kubo, Usha B. Tedrow, Lynda M. Rose, Paul M. Ridker, David Conen, Tatsuhiko Tsunoda, Tetsushi Furukawa, Nona Sotoodehnia, Siyan Xu, Naoyuki Kamatani, Daniel Levy, Yusuke Nakamura, Babar Parvez, Saagar Mahida, Karen L. Furie, Jonathan Rosand, Raafia Muhammad, Bruce M. Psaty, Thomas Meitinger, Siegfried Perz, H.-Erich Wichmann, Jacqueline C. M. Witteman, W. H. Linda Kao, Sekar Kathiresan, Dan M. Roden, Andre G. Uitterlinden, Fernando Rivadeneira, Barbara McKnight, Marketa Sjogren, Anne B. Newman, Yongmei Liu, Michael H. Gollob, Olle Melander, Toshihiro Tanaka, Bruno H. Ch Stricker, Stephan B. Felix, Alvaro Alonso, Dawood Darbar, John Barnard, Daniel I. Chasman, Susan R. Heckbert, Emelia J. Benjamin, Vilmundur Gudnason, Stefan Kaab, 44, 6, 670-675, Nature genetics, 2012 Jun, PMID: 22544366 PMCID: PMC3366038,
  • The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era. Marylyn D. Ritchie, 131, 10, 1615-1626, Human genetics, 2012 Oct, PMID: 22923055 PMCID: PMC3432217,
  • Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Leah E. Mechanic, Huann-Sheng Chen, Christopher I. Amos, Nilanjan Chatterjee, Nancy J. Cox, Rao L. Divi, Ruzong Fan, Emily L. Harris, Kevin Jacobs, Peter Kraft, Suzanne M. Leal, Kimberly McAllister, Jason H. Moore, Dina N. Paltoo, Michael A. Province, Erin M. Ramos, Marylyn D. Ritchie, Kathryn Roeder, Daniel J. Schaid, Matthew Stephens, Duncan C. Thomas, Clarice R. Weinberg, John S. Witte, Shunpu Zhang, Sebastian Zollner, Eric J. Feuer, Elizabeth M. Gillanders, (c) 2011 Wiley Periodicals, Inc., 36, 1, Genetic epidemiology, 2012 Jan, PMID: 22147673 PMCID: PMC3368075,
  • High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Laura J. Rasmussen-Torvik, Jennifer A. Pacheco, Russell A. Wilke, William K. Thompson, Marylyn D. Ritchie, Abel N. Kho, Arun Muthalagu, M. Geoff Hayes, Loren L. Armstrong, Douglas A. Scheftner, John T. Wilkins, Rebecca L. Zuvich, David Crosslin, Dan M. Roden, Joshua C. Denny, Gail P. Jarvik, Christopher S. Carlson, Iftikhar J. Kullo, Suzette J. Bielinski, Catherine A. McCarty, Rongling Li, Teri A. Manolio, Dana C. Crawford, Rex L. Chisholm, (c) 2012 Wiley Periodicals, Inc., 5, 5, 394-399, Clinical and translational science, 2012 Oct, PMID: 23067351 PMCID: PMC3521536,
  • Systems and genome-wide approaches unite to provide a route to personalized medicine. Barbara E. Stranger, Johan Bjorkegren, M. Eileen Dolan, Marylyn D. Ritchie, 4, 3, Genome medicine, 2012 Mar 30, PMID: 22494390 PMCID: PMC3446279,
  • Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. Sarah A. Pendergrass, Scott M. Dudek, Dana C. Crawford, Marylyn D. Ritchie, 5, 1, BioData mining, 2012, PMID: 22682510 PMCID: PMC3476448,
  • Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Emily R. Holzinger, Benjamin Grady, Marylyn D. Ritchie, Heather J. Ribaudo, Edward P. Acosta, Gene D. Morse, Roy M. Gulick, Gregory K. Robbins, David B. Clifford, Eric S. Daar, Paul McLaren, David W. Haas, 22, 12, 858-867, Pharmacogenetics and genomics, 2012 Dec, PMID: 23080225 PMCID: PMC3614365,
  • Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies. Emily R. Holzinger, Marylyn D. Ritchie, 13, 2, 213-222, Pharmacogenomics, 2012 Jan, PMID: 22256870 PMCID: PMC3350322,
  • Predicting clopidogrel response using DNA samples linked to an electronic health record. J. T. Delaney, A. H. Ramirez, E. Bowton, J. M. Pulley, M. A. Basford, J. S. Schildcrout, Y. Shi, R. Zink, M. Oetjens, H. Xu, J. H. Cleator, E. Jahangir, M. D. Ritchie, D. R. Masys, D. M. Roden, D. C. Crawford, J. C. Denny, 91, 2, 257-263, Clinical pharmacology and therapeutics, 2012 Feb, PMID: 22190063 PMCID: PMC3621954,
  • Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. Emily R. Holzinger, Todd Hulgan, Ronald J. Ellis, David C. Samuels, Marylyn D. Ritchie, David W. Haas, Asha R. Kallianpur, Cinnamon S. Bloss, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Christina M. Marra, Justin C. McArthur, J. Allen McCutchan, Susan Morgello, David M. Simpson, Donald R. Franklin, Debralee Rosario, Doug Selph, Scott Letendre, Igor Grant, 18, 6, 511-520, of neurovirology, 2012 Dec, PMID: 23073667 PMCID: PMC3587171,
  • Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Andrea H. Ramirez, Yaping Shi, Jonathan S. Schildcrout, Jessica T. Delaney, Hua Xu, Matthew T. Oetjens, Rebecca L. Zuvich, Melissa A. Basford, Erica Bowton, Min Jiang, Peter Speltz, Raquel Zink, James Cowan, Jill M. Pulley, Marylyn D. Ritchie, Daniel R. Masys, Dan M. Roden, Dana C. Crawford, Joshua C. Denny, 13, 4, 407-418, Pharmacogenomics, 2012 Mar, PMID: 22329724 PMCID: PMC3361510,
  • A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data. Carrie C. Buchanan, Eric S. Torstenson, William S. Bush, Marylyn D. Ritchie, 19, 2, 289-294, of the American Medical Informatics Association : JAMIA, 2012 Mar-Apr, PMID: 22319179 PMCID: PMC3277631,
  • A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Stefan Kaab, Dana C. Crawford, Moritz F. Sinner, Elijah R. Behr, Prince J. Kannankeril, Arthur A. M. Wilde, Connie R. Bezzina, Eric Schulze-Bahr, Pascale Guicheney, Nanette H. Bishopric, Robert J. Myerburg, Jean-Jacques Schott, Arne Pfeufer, Britt-Maria Beckmann, Eimo Martens, Taifang Zhang, Birgit Stallmeyer, Sven Zumhagen, Isabelle Denjoy, Abdennasser Bardai, Isabelle C. Van Gelder, Yalda Jamshidi, Chrysoula Dalageorgou, Vanessa Marshall, Steve Jeffery, Saad Shakir, A. John Camm, Gerhard Steinbeck, Siegfried Perz, Peter Lichtner, Thomas Meitinger, Annette Peters, H.-Erich Wichmann, Christiana Ingram, Yuki Bradford, Shannon Carter, Kris Norris, Marylyn D. Ritchie, Alfred L. Jr George, Dan M. Roden, 5, 1, 91-99, Circulation. Cardiovascular genetics, 2012 Feb 1, PMID: 22100668 PMCID: PMC3288202,
  • The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Kelly A. Birdwell, Ben Grady, Leena Choi, Hua Xu, Aihua Bian, Josh C. Denny, Min Jiang, Gayle Vranic, Melissa Basford, James D. Cowan, Danielle M. Richardson, Melanie P. Robinson, Talat Alp Ikizler, Marylyn D. Ritchie, Charles Michael Stein, David W. Haas, 22, 1, Pharmacogenetics and genomics, 2012 Jan, PMID: 22108237 PMCID: PMC3237759,
  • Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Stephanie M. Fullerton, Wendy A. Wolf, Kyle B. Brothers, Ellen Wright Clayton, Dana C. Crawford, Joshua C. Denny, Philip Greenland, Barbara A. Koenig, Kathleen A. Leppig, Noralane M. Lindor, Catherine A. McCarty, Amy L. McGuire, Eugenia R. McPeek Hinz, Daniel B. Mirel, Erin M. Ramos, Marylyn D. Ritchie, Maureen E. Smith, Carol J. Waudby, Wylie Burke, Gail P. Jarvik, 14, 4, 424-431, Genetics in medicine : official journal of the American College of Medical Genetics, 2012 Apr, PMID: 22361898 PMCID: PMC3723451,
  • Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. J. S. Schildcrout, J. C. Denny, E. Bowton, W. Gregg, J. M. Pulley, M. A. Basford, J. D. Cowan, H. Xu, A. H. Ramirez, D. C. Crawford, M. D. Ritchie, J. F. Peterson, D. R. Masys, R. A. Wilke, D. M. Roden, 92, 2, 235-242, Clinical pharmacology and therapeutics, 2012 Aug, PMID: 22739144 PMCID: PMC3785311,
  • Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits. Keyue Ding, Khader Shameer, Hayan Jouni, Daniel R. Masys, Gail P. Jarvik, Abel N. Kho, Marylyn D. Ritchie, Catherine A. McCarty, Christopher G. Chute, Teri A. Manolio, Iftikhar J. Kullo, Copyright (c) 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved., 87, 5, 461-474, Mayo Clinic proceedings, 2012 May, PMID: 22560525 PMCID: PMC3538470,
  • Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. Marylyn D. Ritchie, Shane Rowan, Gayle Kucera, Tanya Stubblefield, Marcia Blair, Shannon Carter, Dan M. Roden, Dawood Darbar, Copyright (c) 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved., 60, 13, 1173-1181, of the American College of Cardiology, 2012 Sep 25, PMID: 22818067 PMCID: PMC3448817,
  • Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. David R. Crosslin, Andrew McDavid, Noah Weston, Sarah C. Nelson, Xiuwen Zh Eugene Hart, Mariza de Andrade, Iftikhar J. Kullo, Catherine A. McCarty, Kimberly F. Doheny, Elizabeth Pugh, Abel Kho, M. Geoffrey Hayes, Stephanie Pretel, Alexander Saip, Marylyn D. Ritchie, Dana C. Crawford, Paul K. Crane, Katherine Newton, Rongling Li, Daniel B. Mirel, Andrew Crenshaw, Eric B. Larson, Chris S. Carlson, Gail P. Jarvik, 131, 4, 639-652, Human genetics, 2012 Apr, PMID: 22037903 PMCID: PMC3640990,

Publications